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Name : Kenza Abdelhadi Mansoor

Academic Rank: Associate Professor

Administrative Position : Faculty Academic Member

Office 119 Ext No 8113

Email : kmansoor@uop.edu.jo

Specialization: Pharmacy

Graduate Of: University of Manchester

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Qualification

Qualification	University	Country	Year
B.Sc.	University of Petra	Jordan	2001
Ph.D	University of Manchester	United Kingdom	2006

Professional & Administrative Experience

2001-2002: Chief Pharmacist, Al-Hikma Modern Hospital, Zarqa, Jordan

2004-2006: Teaching Assistant, School of Pharmacy & Pharmaceutical Sciences, University of Manchester,UK

2006-2011: Assistant Professor, Faculty of Pharmacy & Medical Sciences, AAU, Amman, Jordan

2008-2011: Assistant Dean for Quality Assurance Affairs, Faculty of Pharmacy & Medical Sciences, AAU, Amman, Jordan

2009-2011: Head of Pharmaceutical Sciences Department, Faculty of Pharmacy & Medical Sciences, AAU, Amman, Jordan

2012-now: Assistant Professor, Faculty of Pharmacy & Medical Sciences,UOP, Amman, Jordan

Teaching Experience

2012-now: Phytochemistry II for 3rd year students,Faculty of Pharmacy & Medical Sciences,UOP,Amman,Jordan

: Herbal Medicine for 4th & 5th tear students, Faculty of Pharmacy & Medical Sciences, UOP, Amman

: Phytochemistry for MSc students, Faculty of Pharmacy & Medical Sciences, UOP, Amman, Jordan

2006-2011 : Phytotherapy for 4th & 5th year students, Faculty of Pharmacy & Medical Sciences, AAU, Amman, Jordan

: Phytochemistry (practical) for 3rd year students, Faculty of Pharmacy & Medical Sciences, AAU, Amman, Jordan

: Pharmacognosy (Theoretical & practical) for 3rd year students, Faculty of Pharmacy & Medical Sciences, AAU, Amman, Jordan

2004-2006 : Medicinal chemistry for 3rd year students, School of Pharmacy & Pharmaceutical Sciences, University of Manchester, UK

2004-2006 : Forensic sciences for 3rd year students, School of Pharmacy & Pharmaceutical Sciences, University of Manchester, UK

Journal Paper

Pharmaceutical Biolo, " Proanthocyanidins from Ginkgo biloba leaf extract and their radical scavenging activity, Pharmaceutical Biology, 2011 49(5):471-6 " , "",Vol.,No., , , 01/01/2011

Abstract:

Ginkgo biloba L (Ginkgoaceae) is a traditional herbal medicinal plant for the treatment of mild to moderate cognitive disorders, tinnitus, and dementia. These uses may be correlated with the presence of radical scavenging compounds. The chemical composition and the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity of the flavan-3-ols and proanthocyanidins from G. biloba were studied. The compounds have been isolated using column chromatography on Sephadex LH-20 and MCI gel and the structures were determined on the basis of 1D- and 2D-NMR (HSQC, HMBC) experiments of their peracetylated derivatives, MALDI-TOF-MS and by acid-catalyzed degradation with phloroglucinol. The DPPH radical scavenging activities of the compounds were investigated. The new trimeric prodelphinidin, epigallocatechin-(4β→8)-epigallocatechin-(4β→8)-catechin (compound 7), has been isolated from the air-dried leaves of the title plant, in addition to catechin, epigallocatechin, gallocatechin, and three dimeric proanthocyanidins. The dimeric prodelphinidin epigallocatechin-(4β→8)-epigallocatechin (compound 6) showed the strongest DPPH radical scavenging activity, with IC(50) 1.7 μg/mL, 10 times more active than the positive control, BHT (IC(50) 17.3 µg/mL), followed by the new trimeric proanthocyanidin epigallocatechin-(4β→8)-epigallocatechin-(4β→8)-catechin with IC(50) 2.1 µg/mL. The crude extract exhibited high DPPH radical scavenging activity with IC(50) 15.5 µg/mL comparable with that of BHT. The results showed that all the isolated compounds from the tannin fraction exhibited potent free radical scavenging activities, which were higher than that of BHT, suggesting that the condensed tannins from G. biloba leaves strongly contribute to the overall antioxidant effects.

Scientica Pharmaceut, " Polyphenols from Ginkgo biloba leaf extract, Scientica Pharmaceutica, 2010 28;78(4):897-907 " , "",Vol.,No., , , 01/01/2010

Abstract:

By Sephadex LH-20 gel chromatography of an extract from Gingko biloba leaves, polymeric proanthocyanidins were eluted after the fractions of flavonol glycosides and biflavone glycosides. A purified proanthocyanidin polymer accounted for 86.6% of the total proanthocyanidins, and for 37.7% of the total antioxidant activity of this leaf extract. For structure elucidation, the polymer was submitted to acidic depolymerization in the presence of phloroglucinol. The structures of the resulting flavan-3-ols and phloroglucinol adducts were determined on the basis of 1D-and reverse 2D-NMR (HSQC, HMBC) spectra of their peracetylated derivatives, MALDI-TOF-MS and CD-spectroscopy. The observations resulting from the degradation with phloroglucinol were confirmed by 13C-NMR spectroscopy of the polymer. The mean molecular weight of the polymeric fraction was estimated to be 9–10 flavan-3-ol-units.

Natural Product Rese, " Antioxidant oligomeric proanthocyanidins from Cistus salvifolius, Natural Product Research, 2006 20 (13):1216-24 " , "",Vol.,No., , , 01/01/2006

Abstract:

The purified proanthocyanidin oligomers of Cistus salvifolius herb extract accounted for 78% of the total proanthocyanidins and 73% of the total antioxidant activity of this extract. To elucidate the structure of the oligomer, it was depolymerized by acid catalysis in the presence of phloroglucinol. The structures of the resulting flavan-3-ols and phloroglucinol adducts were determined on the basis of 1D- and reverse 2D-NMR (HSQC, HMBC) experiments of their peracetylated derivatives, MALDI-TOF-MS and CD spectroscopy. These observations resulting from the degradation with phloroglucinol were confirmed by 13C NMR spectroscopy of the oligomer. The mean molecular weight of the higher oligomeric fraction was estimated to be 5–6 flavan-3-ol-units.

Kenza Mansoor, Fadi Qadan, Mathias Schmidt, " Hamamelis virginiana L. leaf extract suppositories in the treatment of hemorrhoids: Non-interventional trial and stability study. " , " Pharmazie",Vol.0,No., Eschborn : Govi-Verlag Pharmazautischer Verlag, Amman, 04/01/2018

Abstract:

Objective: The effectiveness of suppositories containing witch-hazel leaf extract (Hamamelis virginiana L.) and menthol in the treatment of hemorrhoids was assessed in a non-interventional clinical study. The stability of the test preparation was ensured through a formal accelerated stability study.

K Mansoor, F Qadan, M Schmidt, E Mallah, W Abudayyih, K Matalka. , " 2. Stability study and a 14-day oral dose toxicity in rats of plantain leaf extract (Plantago lanceolata L.) syrup. " , "Scientia Pharmaceutica",Vol.,No., Multidisciplinary Digital Publishing Institute, , 03/22/2017

Abstract:

Plants have been used since antiquity to treat and prevent diseases. Plantain (Plantago lanceolata L.) is traditionally used for the treatment of the common cold and associated symptoms such as cough. This study was designed to evaluate the oral toxicity of plantain leaf extract-containing syrup. In

. KA Mansoor, KZ Matalka, FS Qa’dan, R Awad, M Schmidt, " Two new proanthocyanidin trimers isolated from Cistus incanus L. demonstrate potent anti-inflammatory activity and selectivity to cyclooxygenase isoenzymes inhibition. " , "Natural Product Research",Vol.,No., Milton Park, UK : Taylor & Francis Health Sciences, , 09/01/2016

Abstract:

Two new proanthocyanidin trimers have been isolated from Cistus incanus herb; gallocatechin-(4α→6)-gallocatechin-(4α→8)-gallocatechin (compound 1) and epigallocatechin-3-O-gallate-(4ß→8)-epigallocatechin-3-O-gallate-(4ß→8)-gallocatechin (compound 2). The structures were determined on the basis of 1D

AN Zaid, MN Abualhasan, N Jaradat, M Marar, K Mansoor, F Qa’dan, " 4. Development and validation of a new analytical HPLC method for the estimation of carvone in suppositories. " , "Journal of Pharmaceutical Investigation",Vol.,No., Springer Netherlands, , 10/01/2016

Abstract:

Carvone volatile oil is a commercial product that is widely used in the food, cosmetic and pharmaceutical industry due to its fragrance, flavoring and medicinal properties. A validated HPLC method for the qualitative and quantitative analysis of this oil in raw and commercial products is not availab

KZ Matalka, NA Abdulridha, MM Badr, K Mansoor, NA Qinna, F Qadan, " 5. Eriobotrya japonica water extract characterization: an inducer of interferon-gamma production mainly by the JAK-STAT pathway. " , "Molecules",Vol.,No., Basel, Switzerland : MDPI, , 06/01/2016

Abstract:

Eriobotrya japonica (Thunb.) Lindl.(Loquat)(EJ) has been used as a medicinal plant to treat chronic bronchitis, coughs, phlegm, high fever and gastro-enteric disorders. Since the traditional use of EJ is related to modulating inflammation processes, our earlier studies on EJ leaves were performed on

Chapter in a Book

2007, volume 1, page, " Gas Chromatography: Terpinoids ,Encyclopaedia of Separation Science, Elsevier, Academic Press, 2007, volume 1, pages 1-10 " , "",Vol.,No., , , 01/01/2007

Conference paper

36th International S, " Stability of Australian tea tree oil (Melaleuca alternifolia) individually and in combination with topical O/W emulsions, 36th International Symposium of Essential Oils, Budapest,2005 " , "",Vol.,No., , , 01/01/2005

54th Annual Congress, " Antioxidant oligomeric proanthocyanidins from Cistus salvifolius, 54th Annual Congress on Medicinal Plant Research, Helsinki, 2006 " , "",Vol.,No., , , 01/01/2006

The Jordanian Intern, " Stability of curcuminoids in Javanese turmeric (C. xanthorrhiza) extract formulated into O/W emulsions ,The Jordanian International Pharmaceutical Conference, Al-Zaytoonah Private University of Jordan, 2006 " , "",Vol.,No., , , 01/01/2006

The First Regional S, " Stability of salicin and proanthocyanidins in willow bark (Salix alba) extract formulated into O/W emulsions, The First Regional Scientific Conference on Traditional Arabic and Islamic Medicine, Amman, Jordan, 2007 " , "",Vol.,No., , , 01/01/2007

Arab Pharmacists Con, " Microbiological Determination of Pure and Formulated Tea Tree Oil and α-Terpineol, Arab Pharmacists Conference, Amman, Jordan, 2008 " , "",Vol.,No., , , 01/01/2008

"Pharmacy is a pivot, " Contraindications of natural drugs during pregnancy, 2nd Scientific day of Pharmaceutical Association Contraindications of natural drugs during pregnancy, 2nd Scientific day of Pharmaceutical Association "Pharmacy is a pivotal profession in community health", Zarqa, Jordan 2011 " , "",Vol.,No., , , 01/01/2011

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