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Journal Paper

E.Mallah, N.Kuhn, Ma, " Nucleophilic Aromatic Substitution with 2,3-Dihydro-1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene " , "Z.Naturforschung",Vol.64b,No., , Tuebingen, Germany, 06/13/2009 Abstract:
Starting with the pioneering work of Meisenheimer, the addition-elimination mechanism of the nucleophilic aromatic substitution has found continuous interest. More recently, this type of reaction has been extended to perfluorinated arenes predominantly by reactions with anionic nucleophiles. Much less is known on the substitution of fluoride by neutral nucleophiles such as amines and in situ prepared nucleophilic carbenes.2,3-Dihydro-1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene (1) reacts with excess of hexafluorobenzene in the presence of borontrifluoride diethyletherate to give 1,3-diisopropyl-4,5-dimethyl-2-(perfluorophenyl)imidazolium tetrafluoroborate (2). Solution of 2 exhibit an equilibrium consisting also of hexafluorobenzene and 2,2’-(perfluoro-1,4-phenylene)bis(1,3-diisopropyl-4,5-dimethylimidazolium bis(tetrafluoroborate) (3) which is obtained from 1 and hexafluorobenzene in the ration 2:1 in a preparative scale. Similar to 2, 2-(4-cyano-2,3,5,6-tetrafluorophenyl)-1,3-diisopropyl-4,5-dimethylimidazolium tetrafluoroborate (4), 2-(2,4-dicyano-2,5,6-trifluorophenyl)-1,3-diisopropyl-4,5-dimethylimidazolium tetrafluoroborate (5), and 2-(4,6-difluoro-1,3,5-triazin-2-yl)-1,3-diisopropyl-4,5-dimethylimidazolium tetrafluoroborate (6) are obtained from 1 and perfluorobenzonitrile, 1,3-dicyano-2,4,5,6-tetrafluorobenzene, and 2,4,6-trifluoro-1,3,5-triazin, respectively. Download




Qutaiba Abu-Salem, N, " Stepwise Aldol Addition and Cyanhydrin Formation with Acetone and Thallous Cyanide " , "Z. Naturforsch",Vol.63b,No., , Tuebingen, Germany, 06/06/2008
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Ahmed Abu-Rayyan, Qu, " C-H-O Hydrogen Bonds in Imidazolium Carboxylates " , "Z. Naturforsch.",Vol.63b,No., , Tuebingen, Germany, 08/02/2008
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Ahmed Abu-Rayyan, Qu, " Acetylacetonate Ion as its E/Z-Isomer in 1,3-Diisopropyl-4,5-dimethylimidazolium Acetylacetonate " , "Z. Naturforsch.",Vol.63b,No., , Tuebingen, Germany, 09/02/2008
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Norbert Kuhn, Eyad M, " Imidazolium Phenolates " , "Z. Naturforsch",Vol.64b,No., , Tuebingen, Germany, 03/20/2009
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Qutaiba Abu-Salem, K, " Hydrogen-Bonded Phosphorus Acids, Synthesis and Structure of Imidazolium-Containing Salts of Hydrogenphosphonate and Phenylphosphonate " , "Jordan Journal of Chemistry (JJC)",Vol.6,No.2, , Amman, Jordan, 02/12/2011
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Eyad Mallah, Qutaiba, " Imidazolium Dicyanoargentates " , "Z. Naturforsch.",Vol.66b,No., , Tuebingen, Germany, 02/20/2011
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Eyad Mallah, Qutaiba, " Crystal structure of trimethylsulfoxonium phthalimide, [C3H9SO][C8H4NO2] " , "Z. Kristallogr. NCS",Vol.226,No., , Germany, 06/17/2011
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Kamal Sweidan, Eyad , " 1,3-Diisopropyl-4,5-dimethylimidazolium benzenesulfonate " , "Acta Crystallographica Section E",Vol.E67,No., , , 07/27/2011
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Eyad M Mallah, Moham, " Plasma concentrations of 25-hydroxyvitamin D among Jordanians: Effect of biological and habitual factors on vitamin D status " , "BMC Clinical Pathology",Vol.,No.1472-6890, , , 08/04/2011
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Eyad Mallah, Kamal S, " 2-Bromo-1,3-diisopropyl-4,5-dimethyl-1H-imidazol-3-ium dicyanidoargentate " , "Acta Crystallographica Section E",Vol.E68,No., , , 08/05/2011
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Eyad Mallah a, Kamal, " Nucleophilic substitution approach towards 1,3-dimethylbarbituric acid derivativesdnew synthetic routes and crystal structures " , "Tetrahedron",Vol.68,No., , , 11/28/2011
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Eyad Mallah, Kamal S, " 1,3-diisopropyl-4,5-dimethyl-2-bromoimidazolium dicyanoargentate " , "Acta Cryst section E",Vol.,No., , , 11/07/2012
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Qutaiba Abu-Salem, E, " On Hydrolysis of Thallium phthalimide. The crystal structure of Dimorph Polymeric Thallium(I) Complex, {Tl[(H)phthalate]}n, " , "Jordan Journal of Chemistry (JJC)",Vol.,No., , , 11/07/2012
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Wael Abu Dayyih, Noo, " Development and Validation of HPLC Method for Some Azoles in Pharmaceutical Preparation " , "International Journal of Pharmacy and Pharmaceutical Sciences (IJPPS)",Vol.,No., , , 12/20/2012
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Nidal A. Qinna , Eya, " Effect of Licorice and Grapefruit Juice on Paracetamol Pharmacokinetics in Human Saliva " , "International Journal of Pharmacy and Pharmaceutical Sciences (IJPPS)",Vol.,No., , , 11/07/2012
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Khalid Z. Matalka, M, " Enhancing Doxorubicin-Induced MCA-Fibrosarcoma Cytotoxicity by an Eriobotrya japonica Hydrophilic Butanol-Treated Extract through Natural Killer Cells Activation " , "Journal of Cancer Science & Therapy (JCST)",Vol.,No., , , 12/20/2012
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Khalid Z. Matalka, F, " Anti-inflammatory aminoacetylenic isoindoline-1,3-dione derivatives modulate cytokines production from different spleen cell populations " , "International Immunopharmacology",Vol.,No., , , 12/20/2012
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Wael Abu Dayyih, Sar, " Development and Validation of a Reversed Phase HPLC Method For Simultaneous Estimation of Some Prils in Drug Forms " , "International Journal of Pharmacy and Pharmaceutical Sciences (IJPPS)",Vol.,No., , , 12/20/2012
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3. Riad Awad, Eyad M, " Bis(methylsulfonyl) methane " , "Acta Cryst E70",Vol.,No., , , 01/02/2014




Wael Abu Dayyih, Eya, " Crystal structure of 1, 3-Diisopropyl-4, 5-dimethylimidazolium oxalic acid monomethyl ester " , "Z.Kristallogr. , NCS ",Vol.,No., , , 11/09/2013
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Wael A. Abu Dayyih, , " A stability-indicating High Performance Liquid Chromatographic (HPLC) Assay for The Determination of Cefaclor in Biological Fluid " , "Latin American Journal of Pharmacy (Lat. Am. J. Pharm.)",Vol.,No., , , 12/09/2013
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Wael A. Abu Dayyih, , " Development and Validation of a Stability –Indicating HPLC Method for Determination of Bupivacaine in Human Plasma " , "International Journal of Pharmaceutical Analysis (IJPA)",Vol.,No., , , 08/09/2013
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Riad Awad, Hanan Ham, " Quality control of cinnamic acid in traditional medicinal plants in Jordan using HPLC " , "International Journal of Pharmacy and Pharmaceutical Sciences (IJPPS)",Vol.,No., , , 06/06/2014
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T. Abu Tbeekh, Wael , " Pomegranate juice effects on pharmacokinetic parameters of metronidazole by using HPLC-MS " , "world journal of pharmacy and pharmaceutical sciences",Vol.,No., , , 04/17/2014
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Wael Abu Dayyih, Dan, " Pethidine Level in Jordanian Women and their Newborns during Labor after a Single Intravenous Dose " , "Int J Clin Anesthesiol ",Vol.,No., , , 10/10/2014
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Eyad Mallah, Kamal S, " Crystal structure of 1,3-dicyclohexyl-4,5-dimethyl-1H-imidazol-3-ium-2-carbodithioate chloroform monosolvate " , "Acta Cryst. E70",Vol.,No., , , 11/04/2014
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16. Eyad Mallah*, Nibras Al Ani, Wael Abu Dayyih, Nidal Qinna, Riad Awad, Kamal Sweidan and Tawfiq Arafat, " Simultaneous Determination of Sildenafil and Glimepiride in Rat Plasma by Using LC-Ms Method and their Applications in Pharmacokinetic Interactions " , "JSM Clinical Pharmaceutics (J Clin. Pharm)",Vol.,No., SciMed, , 06/06/2014
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15. Wael Abu Dayyih, Ala’a Al-Fayez, Lina Tamimi, Eyad Mallah and Tawfiq Arafat, " Simultaneous Determination of Atorvastatin, Glimepiride and Amlodipine in solution and plasma matrix using HPLC/ UV method, " , "Journal of Chemical and Pharmaceutical Research",Vol.,No., JCPR, , 10/10/2014
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Lina Tamimi, Wael Abu Dayyih, Nidal Qinna, Eyad Mallah and Tawfiq Arafat., " Pioglitazone HCl Levels and its Pharmacokinetic Application in Presence of Sucralose in Animals Serum by HPLC method " , "Pharmaceutica Analytica Acta",Vol.,No., Anal, , 12/05/2014
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13. Riad Awad, Eyad Mallah*, Kamal Sweidan, Ahmed Al-Sheikh, Wael Abu Dayyih, and Manfred Steimann, " Synthesis and Crystal Structure of 1,3-diisopropyl-4, 5-dimethylimidazolium 4-methyl- benzenesulfinate " , "Journal of Chemical and Pharmaceutical Research",Vol.,No., JCPR, , 12/09/2014
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12. Eyad Mallah*, Basel Arafat, Ahmad Abu Awwad, Wael Abu Dayyih, Mohammed Mima, Tawfiq Arafat, " Comparative Bioavailability of Two Different Quetiapine Doses (50 and 200 mg) in Healthy Volunteers by Using LC/MS Method " , "Journal of Chemical and Pharmaceutical Research",Vol.,No., JCPR, , 12/19/2014
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11. Bayan Alkhawaja, Tawfiq Arafat, Eyad Mallah*, Nidal Qinna, Naser Idkaidek, Wael Abu Dayyih, Hamza Alhroub, Adnan Badwan, " Simultaneous Determination of Paracetamol and its Metabolites in Rat Serum by HPLC Method and its Application Supplement-Drug Pharmacokinetic Interaction " , "International Journal of Pharmaceutical Analysis",Vol.,No., IJP, , 12/20/2014
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10. Eyad Mallah*, Ahmed Al-Sheikh, Kamal Sweidan, Wael Abu Dayyih, Manfred Steimann, " Crystal structure of 5-(bis(methylsulfonyl)metzhyl)-1,3-dimethyl-5-(methylsulfonyl)pyrimidine-2,4,6(1H,3H,5H)-trione " , "Acta Cryst.",Vol.,No., Acta, , 01/03/2015
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9. Teeba Al. Shaikhli, Wael Abu Dayyih, Eyad Mallah, Mohammed Hamad, Nidal Qinna, Tawfiq Arafat, " Determination of Atorvastatin Pharmacokinetic Parameters by LC/MS-MS with Traditional Liquorice Beverage " , "Advances in Analytical Chemistry",Vol.,No., Advances, , 02/06/2015
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8. Riad Awad, Eyad Mallah, Faisal Al-Akayleh, Tawfiq Arafat, Kenza Mansoor, Wael Abu Dayyih, " Determination of Parameters for the hydrolysis of Yohimbine HCl at Neutral and Slightly acidic medium " , "International Journal of Pharmacy and Pharmaceutical Sciences (IJPPS)",Vol.,No., IJPPS, , 02/20/2015
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7. Eyad Mallah*, Mohammed Gharaibeh, and Manfred Steimann, " A Theoretical Study on the Thermodynamic Parameters for Some Imidazolium Crystals " , "Journal of Chemical and Pharmaceutical Research",Vol.,No., JCPR, , 03/09/2015
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6. Eyad Mallah, Basel Arafat, Bayan Al khawaja, Wael Abu Dayyih, Ahmed Abu Awad, Hamza Al hroub, Mohammed Hamad, Tawfiq Arafat, " Relative Bioavailability of Ciprofloxacin Doses (750 and 1000) mg in Healthy Male Volunteers by Using HPLC Method " , "Journal of Bioequivalence Studies (J Bioequiv)",Vol.,No., bioeq., , 04/04/2015
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5. Wael Abu Dayyih, Lina Tamimi, Eyad Mallah, Kenza Mansour, Tawfiq Arafat, Mona Bustami, " Saxagliptin Levels and its Pharmacokinetic Application in Presence of Sucralose in Animals Serum by HPLC Method " , "International Journal of Pharmacy and Pharmaceutical Sciences (IJPPS)",Vol.,No., IJPPS, , 09/11/2015
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4. Sally Oumeish, Eyad Mallah, Wael Abu Dayyih, Mohammed Hamad, Walid Abu Rayyan, Mona Bustami, Tawfiq Arafat, " Serum concentrations of Magnesium among Jordanians: Effect of cardiovascular disease on magnesium levels " , "Journal of Chemical and Pharmaceutical Research",Vol.,No., JCPR, , 10/25/2015
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Moh'd Salemaldajeh, Eyad Mallah, Riad Awad, Wael Abu Dayyih, Feras Darwish Elhajjib, Israa H. Al-anic, Basmah A. Othmana and Tawfiq Arafata, " Determination of carbamazepine in rat plasma in the presence of licorice juice by using HPLC and its pharmacokinetic applications " , "Journal of Chemical and Pharmaceutical Research",Vol.,No., JCPR, , 12/17/2015
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Moh'd Salemaldajeh, Eyad Mallah, Riad Awad, Wael Abu Dayyih, Feras Darwish Elhajjib, Israa H. Al-anic, Basmah A. Othmana and Tawfiq Arafata, " Determination of carbamazepine in rat plasma in the presence of licorice juice by using HPLC and its pharmacokinetic applications " , "Journal of Chemical and Pharmaceutical Research",Vol.,No., JCPR, , 12/17/2015
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Eyad M. Mallah, Walid S. Abu Rayyan, Wael A. Abu Dayyih, Feras Darwish Elhajji, Kenza A. Mansour, Ibrahim S. Al-majali, Tawfiq A. Arafat., " Dose-Dependent Synergistic effect of Pomegranate Juice on the Bioavailability of Sildenafil in Rats by Using HPLC Method, " , "Latin American Journal of Pharmacy",Vol.,No., (formerly Acta Farmacéutica Bonaerense), , 12/07/2016
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Riad Awad, Eyad Mallah, Bayan Al Khawaja, Wael Abu Dayyih, Feras El-Hajji , Khalid Z. Matalka, Tawfiq Arafat, " Pomegranate and licorice juices modulate metformin pharmacokinetics in rats " , "Neuroendocrinology Letters",Vol.,No., Society of Integrated Sciences, , 01/08/2016
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EYAD MALLAH1*, WALID ABU RAYYAN1, WAEL ABU DAYYIH1*, IBRAHIM S. AL-MAJALI3, HAITHAM QARALLEH4, OSAMA YOSEF AL- THUNIBAT5 , NISREEN SEDER2, MONA BUSTAMI1 , LUAY ABU QATOOSAH1 and TAWFIQ ARAFAT1, " Analytical and Comparative Study about the Impact of Lead Homeostasis on Cardiovascular Disorders in Humans " , "Biomedical & Pharmacology Journal",Vol.,No., Oriental Scientific Publishing Company, , 04/11/2018 Abstract:
World health organization reported cardiovascular disease as the first cause of mortality for five consecutive years of 2010-2014. Smoking is an exogenous source of metals contamination in the human body and attributed to 12% of all deaths among adults aged over 30 years. This is the first study car Download




Mohammad Abdulla1 , Eyad Mallah1 , Wael Abu Dayyih1 , Walid Abu Rayyan1 , Feras Darwish El-Hajji2 , Mona Bustami, Kenza Mansour1 , Israa Al-Ani3 , Nisreen Seder4 and Tawfiq Arafat1, " Influence of Energy Drinks on Pharmacokinetic Parameters of Sildenafil in Rats " , "Biomedical & Pharmacology Journal",Vol.,No., IJPPS, , 09/03/2018
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LAYALI ABU ALADASS1 , EYAD MALLAH1*, MOHAMMED HAMAD2 , WAEL ABU DAYYIH1 , DA'SAN M. M. JARADAT3*, NASIR M IDKAIDEK1 , SOADAD SALEH1 , LUAY ABU-QATOUSEH1 , MONA BUSTAMI1 , YAHYA H. F. ALQUDAH3 , TAWFIQ, " FACTORS AFFECTING COENZYME COBALAMIN (VITAMIN B12) LEVELS IN HEALTHY AND PATIENT INDIVIDUALS FROM PETRA REGION (JORDAN) " , "IJBPAS",Vol.8,No., Abridge laboratory, Amman, 01/08/2019
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Fatima shahin, Eyad Mallah, Reem Emad, Luay Abu-Qatouseh, Wael Abu Dayyih, Feras Darwish El-hajji, Kenza Mansoor, Mona Bostamia , Kamal Sweidanc, Tawfiq Arafatd, " Evaluation of lipid lowering effect of milk thistle (silybum marianum) in comparison with rosuvastatin in rats by using ACE-Alera® analyzer " , "INTERNATIONAL JOURNAL OF BIOLOGY AND BIOMEDICAL ENGINEERING",Vol.14,No., NAUN, Netherland, 07/18/2020 Abstract:
Dyslipidemia is a metabolic disorder that is characterized with an elevation in the cholesterol serum levels that can be treated with various hypolipidemic drugs like rosuvastatin. The present study was undertaken to determine and evaluate the hypolipidemic effect of milk thistle seeds extract Download




Zaineh Q. Tafesh , Kenza A. Mansoor , Nidal A. Qinna , Feras D. El-Hajji , Tawfiq A. Arafat, Luay F. Abu-Qatouseh , Bayan Y. Ghanim , Iman A. Basheti , Eyad M. Mallah1, " Reproductive safety assessment of Thymus vulgaris L. extract and quantification of thymol sulfate in pregnant rats and fetuses using a validated LC/MS method of analysis " , "Journal of Applied Pharmaceutical Science",Vol.11,No., crossmark, India, 06/01/2021 Abstract:
The current study aimed to investigate the safety of ingesting standardized thyme extract (Thymus vulgaris L.) during pregnancy in rats. For this purpose, postmortem examination and thymol sulfate (TS) concentration in maternal and fetal effluent extracts were determined. TS concentrations were an Download