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Name : Najah Al-Muhtaseb

Academic Rank: Associate Professor

Administrative Position : Faculty Academic Member

Office 8203       Ext No 8203

Email :

Specialization: Biochemistry

Graduate Of: Bath University






    Kuwaitt University
    Bath University
    United Kingdom

  • Journal Paper

      Journal of Mollecular cell Cardiology 17;785-796 Download

      Diabetes care, 12: 325-331 Download

      Atherosclerosis, 77: 131-138 N Al Muhtaseb, N HAYAT, and M AL Khafaj Download

      Hormones and Metabolism Research 21, 9, 463-532 s saleh al muhtaseb n gumma ka ka mubarak and d shaker Download

      Acta. diabetol Lat 27 1 45-56 Najah AL Muhtaseb, Abdul Razzak Al Yousof J S Bajaj Download

      Diabetic Medicine 1991 8 n al muhtaseb, abdul razzak al yousof and j s bajaj Download

      najah al muhtaseb abdul al razzak al yousof Annals of Saudi Medicine 12 3 1992 page 252=257 Download

      najah al muhtaseb abdul razzak al yousof j s bajaj The journal of pediatrics 1992 Download

      Tawfiq Arafat Amal kaddoumi najah al muhtaseb et al advances in therapy 11 6 1994 320-330 Download

      N AL Muhtaseb j s bajaj J Pharm.Sci. 36 no 1-6 pp 125-136 Download

      Najah Al Muhtaseb, " Lipoproteins lipid and apoliproteins A1 A2 B C11 C111andE in type 1 and type 11 Diabetes mellitus in young arab males " , "",Vol.,No., , , 09/14/1998 Abstract:
      Najah al muhtaseb Bull fac. Pharm. Cairo Univ. 1998 36 2 Download

      Najah Al- Muhtaseb 1, " The role of Human xanthine oxidoreductase (HXOR), anti-HXOR antibodies and microorganisms. " , "rheumatology international ", press, press, springer, germany, 11/05/2011 Abstract:
      This work is to investigate the levels of human xanthine oxidoreductase (HXOR), its antibodies and microorganisms in synovial fluid of patients with untreated rheumatoid joint diseases. Synovial fluids were collected from sixty four patients with rheumatoid joint diseases. Sixty four age matched individuals were included as control. Xanthine oxidoreductase (XOR) proteins level and anti XOR antibodies were determined in the blood and synovial fluid, using human XOR as antigen, by enzyme linked immunosorbent (ELISA) assay. Synovial fluids were cultured for bacteria and fungi. The titers of XOR protein in the synovial fluid of patients with rheumatoid arthritis were 90.43 ± 23.37 μg/ml (mean ± SD, n=29) and up to 62.42 ± 8.74 μg/ml (mean ± SD, n=35) in other joint inflammation. Anti-HXOR antibodies titers in patients were (167.72 ± 23.64 μg/ ml, n= 64) which was significantly higher in rheumatoid arthritis patients. The results indicated that anti-HXOR antibodies in synovial fluids have a protective role as high concentrations against XOR were detected in inflammatory arthritis. These antibodies play a role in eliminating XOR from synovial fluids. However, immune complex formation could activate complement and participate in propagating the inflammatory cycle. Synovial aspirate ordinary microbial cultures were negative for any bacteria or fungi but that does not exclude organisms of special culture requirements. Download

      Najah Al- Muhtaseb 1, " Dyslipidemia and Xanthine Oxidoreductase level in Jordanian Patients with Rheumatoid Arthritis. " , "European Journal of Scientific Research ",Vol.99,No.1, EJSR, UK, 04/08/2013 Abstract:
      Context: Rheumatoid arthritis (RA) is associated with an excess mortality from cardiovascular disease which might be due to an increased prevalence of cardiovascular risk factors such as dyslipidemia, and free radical generating enzyme such as xanthine oxidoreductase (XOR). Thus, they appear to be suitable markers for clinical studies of lipid profile and XOR level in patient with RA and related cardiovascular risk. Objectives: of the study were to assess the prevalence of blood dislipidemia and the levels of blood and synovial XOR in Jordanian patients with untreated active rheumatoid joint diseases and to investigate the clinical and biological associated factors. Methods: Synovial fluids and blood were collected from one hundred twenty seven patients with active RA (63 male and 64 female). One hundred eleven age matched individuals were included as control. Blood lipid profile, apolipoproteins (Apo), blood and synovial XOR proteins level were determined. Results: the levels of patient serum cholesterol (C), low density lipoprotein (LDL)-Cholesterol, Apo B, triglyceride (TG), very low density lipoprotein (VLDL-TG), LDL-TG, Apo C-III, Apo C-III/TG, Apo B/Apo A-I, and LDL-C/high density lipoprotein (HDL)HDL2-C ratios were significantly increased in RA patients. A significant reduction in the levels of HDL-, HDL2-, HDL3-C, serum Apo A-I, ApoA-II, HDL-Apo A-I, and HDL2-C/HDL3-C ratio were found in RA patients compared to healthy controls. Increased XOR in serum and synovial fluid were observed in the RA patients studied. . Conclusions: Abnormalities in lipids, lipoproteins, apolipoproteins and XOR were found in RA patients. Our data favor an enhanced affinity towards atherosclerosis in these patients. Management of dyslipidemia should consider as a part of cardiovascular risk management in RA patients. Attention must be paid to lipids profile for those RA patients with previous history of a cardiovascular event. Download

      Zuhair Muhi-eldeen?1, " Synthesis and pharmacological evaluation of N-[4-(t-amino)-2-butynyloxy] phthalimides. " , "IOSR Journal of Pharmacy ",Vol.2,No.1, IOSR, india, 01/01/2013 Abstract:
      A series of aminoacetylenicoxyphthalimide namely N-[4-(t-amino)-2-butynyloxy] phthalimides were synthesized from the reaction of N-hydroxyphthalimide with propargyl bromide in sodium ethoxide to generate N-(2-butynyloxy)phthalimide. The desired compounds were prepared through Mannich reaction of N-(2-butynyloxy)phthalimide with formaldehyde, appropriate amine in peroxide-free dioxin and cuprous chloride as catalyst. The N-[4-(t-amino)-2-butynyloxy] phthalimides were investigated for their rectal temperature, motor activity and palpebral pitosis effects in comparison with harmaline, all compounds showed similar activity to harmaline, however compound 4 was more potent than harmaline. . Download

      N. Al-Muhtaseb, M. B, " Bovine circulating human anti milk fat globule membrane antibodies and coronary heart disease. " , "Al-Basaer",Vol.8,No.1, Universty of Petra, Amman, Jordan, 04/06/2004 Abstract:
      Levels of serum anti_bovine milk fat globule membrane (BMFGM) antibodies and anti-xanthine oxidase(XO) antibodies in sera of normal healthy human subjects (300 females and 349 males) and patients who had suffered myocardial infarction(MI)( 287 females and 335 males)from Kuwait University Hospital and Arabic Centre for heart and special Surgery Hospital, Jordan, were determined using a sensitive enzyme-linked immunosorbent assay(ELISA). All subjects were males and females aged between 25 and 40 years. Levels of IgG class antiBMFGM were found to be higher in controls than in MI but with no significant difference in IgG anti-XO antibodies. Levels of IgA anti-BMFGM and anti XO antibodies were significantly higher in MI patients when compared with their corresponding controls. Controversial results were observed when different workers measured IgM antibody titers in the same samples which is likely to be due to infarction factors of IgM aggregation within the assay. NO significant difference was observed in IgM ant-xanthine oxidase antibody levels in MI samples and controls.Anti-mfgm antibodies in female (300 controls and 387 MIs) and in male human sera ( 355 controls 349 MIs) using preparation of membrane antigen from goat, camel and sheep milk showed no significant differences with IgG, IgA and IgM, by comparing the present data with previously publihed results , it was concluded that our results showed that there was no specific class of either anti-(BMFGM) antibodies or xanthine oxidase antibodies (IgG, IgA or IgM) to be elevated in MI patients compared to normal healthy human subjects. Download

      Elham Al-Kaissi 1?, , " The influence of adding antibiotic in treatment of rheumatoid arthritis patients on streptococcus pyogenes carrier rate and on the lipids profile. " , "international journal of pharmacy and pharmaceutical sciences",Vol.7,No.2, academic sciences, , 02/01/2015 Abstract:
      Objective: The main goal is to evaluate the clinical efficacy, safety, and tolerability of antibiotics and methotrexate (MTX) treatment on the disease severity, on Streptococcus pyogenes carrier rate and on the lipid profile of patients with rheumatoid arthritis (RA). Methods: In a 6-months, double –blind trial, 130 patients with active RA were treated for four weeks with MTX therapy at a stable low dose of 12.5 mg/week instructed to receive either levofloxacin (500 mg) or placebo orally once daily while continuing to receive MTX. Before and after the treatment, disease activity parameters, rheumatoid factor (CF), C reactive protein (CRP), anti-streptolysin O (ASO) titer and lipid profile were measured. Throat swab cultures were done on suitable medium. Results: Antibiotic adds to treatment causes a significant reduction in disease activity, lower the side effects and concomitant decrease in MTX treatment dose, most of the lipid levels had returned to baseline levels, decreased S. pyogenes carrier rate from 25-30% to 3.2-6% and lower ASO titers to undetectable. Conclusion: RA patients who are treated with MTX, addition of antibiotics lower the signs, symptoms and risk factors of RA patient and S. pyogenes could be important in the etiopathogenesis of RA. Download

      M. BENBOUBETRA , M. , " Immunohistochemical evidence for xanthine oxidase in human myocardium " , "Sciences & Technologie",Vol.,No.18, Revue semestrielle de i Universite Mentouri-Constantine, Algerie, 12/17/2002 Abstract:
      Xanthine oxidoreductase (XOR) could be an important source of reactive oxygen species (ROS) in heart. The enzyme is clearly active in rat heart but its present in the human heart is controversial. This study was to detect XOR immunohistochemically in human myocardium using mouse raised monoclonal antibodies to purified human and bovine milk XOR . We assayed the presence of the of the enzyme in explained human heart and compared to rat heart results. Using positive and negative controls, immunoactive XOR in heart was clearly present in the cardiomyocytes and the smooth muscle cells of blood vessels in both species. The endothelial cells showed no staining in the smaller blood vessels . Other data suggest that ROS generating desulpho-type of XOR. Present in rat heart. Inactive with the substrate( hypo) xanthine is active using NADH as substrate, producing ROS . we speculate that this type of XOR plays a role in radical-induced caediovascular disease. Download

      Mustapha Benboubetra, " Xanthine Oxidoreductase inhibition as source of oxygen and nitrogen reactive species: physiological and biological roles " , "Proceeding of the first African Congress on biology",Vol._,No.=, _, Algeria, 08/07/2000 Abstract:
      Xanthine oxidoreductase (XOR) is a complex molybdoflavoenzyme that has become a focus of research activity because of it ability to generate reactive oxygen species ROS) which plays an important role in many instance of ischemia-reperfusion (IR) injury . inflammation, apoptosis or programmed cell death, cancers and also in normal signal transduction .Proposedmechanisms of XOR-ROS production are commonly based on the properties of the well characterised XORs from bovine milk or rat liver. The enzyme isolated from human breast milk, has unexpectedly low activitives towards conventional reducing substrates such as xanthine , a fact attributed to high content of inactive demolybdo, form. Similar low activity XOR occurs in other human tissues, with the exception of the liver and intestine, which appear to contain high activity enzyme of the bovine milk or ratliver type. However, human milk XOR shows undiminished NADH oxidase activity, generating superoxide and hydrogen peroxide at significant rates. This has led to the proposal of an alternative mechanismfor I-R injury, whereby the generation of dehydrogenase form of XOR, is triggered by elevated levels of NADH. The wide variation in distribution of XOR in human tissues markers it hard to accept that the principal role of the enzyme in purine catabolism , where it catalyses the oxidation of hypoxanthine to xanthine and xanthine to uric acid concomitantly reducing NAD+ ( type D) or molecular oxygen (type O) . Cytokine upregulation of XOR expression has been reported in different epithelial and endothelial including human, cell lines. The major source of microbicidal XOR in neonate is likely to be maternal milk, switching , as infant maures, to internal epithelial cellum which contain high levels of the enzyme . Recently, it was shown that XORis able to generate , in the presence ofNADH , nitric oxide (NO) ,under anaerobic conditions. Nitrate reduction takes place in the molybdenum site of XOR nitric oxide has proven to be a molecule with a wide range of biological significance. It is involved in Download

      ABSTRACT Objective: The lack of information concerning the pharmacological activity of amino acetylenic amide derivatives in which the cyclic amine is aziridine or azetidine promoted our interest to synthesize N-[4-(1-azeridinyl)-2-butynyl] pyrrolide-1,3-dione 4, N-[4-(1-azetidinyl)-2-butynyl] py Download

      Objective: This study aim to investigate the levels of oxidative stress, antioxidants besides uric acid, C-reactive protein (CRP), lipid profile and cardiac biomarker enzymes in young men admitted to the hospital for the first time with acute myocardial infarction (AMI), to investigate any Relations Download
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