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Name : Zuhair Abd Alrazaq Muhi-eldeen

Academic Rank: Professor

Administrative Position : Faculty Academic Member

Office 8310       Ext No 511

Email : zeldeen@uop.edu.jo

Specialization: Pharmaceutical Chemistry

Graduate Of: Ohio State University USA

Qualification

    Qualification

    University

    Country

    Year

    Master's
    Colorado Boulder University USA
    United States of America
    1965
    Ph.D
    Ohio State University USA
    United States of America
    1970



  • Book





      Abstract:
      The book deal with various drugs used in treatment of different diseaes.All chemical structures are drawn.SAR in relation to biological activities are disscused. Download




      Abstract:
      Invole the discution of veriouse strucure related to drugs genarated up to 2010. Download


  • Journal Paper





      Abstract:
      Acute toxicological studies on the extract of Iraqi peganum harmala in rats .Eur.J.of Sci.Research.(2008),Voi.22,no 4.pp494-500. Download




      Abstract:
      synthesis of oxodizole derivatives with potential antimicrobial activity.J.J.of Chemistry.,(2008).Vol.3.no4.pp233-243.




      Abstract:
      Synthesis acetyleic tricyclic compounds as MAO inhibitors .J.of arab university for basic and applied sciences(JANUBAS)(2008)vOL.6,PP47-55. Download




      Abstract:
      Antimicrobial Activity of Some New Oxadiazole Derivatives. Jordan Journal of chemistry Vol. 3 No3 , 2008 PP 233-243 Download




      Abstract:
      Synthesis of Ibuprofen and Indocid salicylamide as prodrugs.Alkufa,J.2006




      Abstract:
      Synthesis and characterization of cyclopropylamine derivatives.Iraqi,J.Pharm.Sci.2006,15(1)23-26. Download




      Abstract:
      Synthesis and Pharmacological Evaluation of N- (4-tert –amino-2-Butynyl) Dibenzazepine. Iraqi J. Pharm. Sci., (2001)




      Abstract:
      Thermal Stability of Some Thiadiazole Derivatives in Relation to Antimicrobial Activity. Thermo chemica Acta., vol. 237, no.1, p. 119-123 (1994). Download




      Abstract:
      Investigation of Possible Relationships Between Thermal Stability And Antibacterial Activity of Some Triazole Derivatives. Iraqi J. Sci., 34, (1993).




      Abstract:
      Kinetics and Mechanism of Hydrolysis of N-[4-(2,6-dimethylpiperidino)-2- butynyloxy] Phthalimide. Iraqi J. Pharm. Sci., 4(1), (1993).




      Abstract:
      Antibacterial Activity of 2-(4-Tert-amino-2-butynyl)thio-5-aryl-1,3,4-Thiadizoles, Iraqi J. Pharm. Sci., 4 (1), (1993)




      Abstract:
      Stability and Kinetics of Hydrolysis of Newly Prepared Esters of Metronidazole As Possible Prodrugs. Iraqi J. Pharm. Sci., 4(1), (1993)




      Abstract:
      Kinetics and Mechanism of Hydrolysis of N-[4-(2,6-dimethylpiperidino)-2- butynyloxy] Phthalimide. Iraqi J. Pharm. Sci., 4(1), (1993)




      Abstract:
      The Synthesis of Glutathionmonoethyl Ester and Its Effect on Sulfhydryl Content of Liver and Kidneys of Rats. Nephron, 192, 62, (1992). Download




      Abstract:
      Synthesis and Antimicrobial Activity of Ni (II), Co(II), Zn(II) and Cd(II) complexes of 3-Mercapto-4-substituted-5-phenyl-4h-1,2, 4-Triazoles. Eur. J. Med. Chem., 101, 27, (1992). Download




      Abstract:
      Glaser Coupling Under Mannich Reaction Conditions. Iraqi J. Sci., 33, (1992) accepted for publication




      Abstract:
      Evaluation of potential chemoprotectants against microcystin-lr hepatotoxicity in mice.J.Applied Toxicol,65,11(1),1991 J.APPL.Toxicol.65,11(1),1991 Download




      Abstract:
      Synthesis and biological evaluation of new acetylenic triazoles. Eur,J,Med,Chem.,1991,26,237. Download




      Abstract:
      The transition to more clinically oriented pharmacy education.J.Clin.Pharm.Therap.1990,15,345-354. Download




      Abstract:
      Synthesis and Antimicrobial Evaluation fof 3-4Tert-amino-2 butynyl - thio and alkly/alkenylthio-4-5-disubstituted 4H-1,2,4-acetylenic triazoles. Eur. j. Med.Chem. vol.26 pp 237-241 (1991) Download




      Abstract:
      Carbon-13-NMR for specific alkynyl amines.Iraqi J.Sci.(1988)132(2)149. Download




      Abstract:
      Synthesis and biological evaluation of thiadiazole benzamides. Eur.J.Med.Chem.(1986)219,21.




      Abstract:
      Kinetic and mechanism of enzymatic hydrolysis of asprinphenylalanineethylester.Int.J.Pharmac.(1985)15,26. Download




      Abstract:
      Synthesis & biological evaluation of 5- Aryl-3-( 4- tert-amino-2- butynyl)-1,3,4-thiadiazol-2-(3H)ones. Eur.J.Med.Chem.,33,20(1),1985 Download




      Abstract:
      Is Aspirin Phenylalanine Ethylester A Prodrug for Aspirin. Am.J. Pharm.Sci. 1093, 72(9), (1983) Download




      Abstract:
      Synthesis&biological evaluation of 2-thio-5-aryl -1,3,4-thiadiazole derivatives.Eur.J.Med.Chem.(1982)470,17.




      Abstract:
      Carbon-13-magnetic resonance of alkynylamines Mag.Reson in Chem., 271.(July,1985) Download




      Abstract:
      synthesis and biological evaluation of 2(4-tert-amono-2-butynyl)thio-5-aryl-1,3,4-thiadiazoles Eur.J. Med. Chem.470,17, 1982 Download




      Abstract:
      Synthesis and Biological Evaluation of L-5-N-4-tert-amino-2-butynyl) carbamoyl-2 Pyrrolidones and their racemates 49-52-1982 Download




      Abstract:
      Synthesis and Biological Evaluation of N,N' -di-4 - t-amino-2-butynyl) Pyromellitic acid diimides 91-93(16,1981) Download




      Abstract:
      Synthesis and Biological Evaluation of N--4-t-amino-2-butynyloxy) and N-4-t-amino-2-butynyl )Phthalimides 85-88(15,1980) Download




      Abstract:
      Synthesis and Pharmacological Properties fo N-4-1-azetidinyl)-2butynyl-2-Pyrrolidone, a highly potent oxotremorine - like agent. J.Pharm. Phamacol. 1980,32,439 85-88(15,1980) Download




      Abstract:
      Acetylene Compounds of Potential Pharmacological Value 89-94 -( 16,1979) Download




      Abstract:
      Pharmacological Studies on the Stereoselective Antihistaminic and Anticholinergic Properties of L9S) - and D(R)- 3 - ethylamino- 1-Phenylpyrrolidine (1) Archives Internationales de Pharmacodynamie et de Therapte Vol.78-192No.,(1,July,1971) Download




      Abstract:
      L(S)-and D(R)-3-Amino-1-phenylpyrrolidines. Stereoselective Antagonists for histamine and Acetyleholine Receptors in Vitro. Journal of Medicinal Chemistry 14,24 1971. Download




      Abstract:
      Synthesis and Biological Evaluation of L-5-N-(4-tert-amino-2-butynyl) Carbamoyl-2-Pyrrolidones and Their recemates. Eur. J.Med.Chem. 49-52 Vol. 17.No. 1 (1982) Download




      Abstract:
      jordan Journal of Pharmaceutical Sciences Zuhair Muhi-eldeen, Vol.2,No.2, July (2009) Download




      Abstract:
      synthesis of novel derivative related to salicylic acid and diflunisal amide derivatives.J.J of Pharm.Sci.(2009),2(2),99-109.




      Arabian Journal of C, " Synthesis and Pharmacological evaluation of aminoacetylenic isoindoline-1,3-dione derivatives as anti-inflammatory agents " , "Arabian Journal of Chemistry",Vol.16,No.2011, Elsevier, International , 12/27/2011 Abstract:
      Synthesis and Pharmacological evaluation of aminoacetylenic isoindoline-1,3-dione derivatives as anti-inflammatory agents Download




      The role of Human xa, " The role of Human xanthine oxidoreductase (HXOR), anti-HXOR antivodies and microorganisms in synovial fluid of patients with joint inflammation " , "",Vol.,No., , , 11/12/2011 Abstract:
      The Role of Human xanthine oxidoreductase (HXOR), anti-HXOR antivodies and microorganisms in synovial fluid of patients with joint inflammation Download




      zuhaiir muhi-eldeen,, " triazoline aminoacetylenic compounds as antimicrobial agents " , "Medicinal chemistry research",Vol.21,No.11(2012), Springer, germany, 10/24/2011



      zuhair muhi-eldeen,e, " synthesis and pharmacological evaluation of N(4(-t-amino)-2-butynyloxy)phthalimides " , "issn:2250-3013",Vol.2/1/2012,No.1, iosr/pharm, international, 01/15/2012 Abstract:
      A series of aminoacetylenicoxyphthalimide namely N-[4-(t-amino)-2-butynyloxy] phthalimides were synthesized from the reaction of N-hydroxyphthalimide with propargyl bromide in sodium ethoxide to generate N-(2-butynyloxy)phthalimide. The desired compounds were prepared through Mannich reaction of N-(2-butynyloxy)phthalimide with formaldehyde, appropriate amine in peroxide-free dioxin and cuprous chloride as catalyst. The N-[4-(t-amino)-2-butynyloxy] phthalimides were investigated for their rectal temperature, motor activity and palpebral pitosis effects in comparison with harmaline, all compounds showed similar activity to harmaline, however compound 4 was more potent than harmaline Download




      Nidai Quina,zuhair m, " Non -selective inhibition of cyclooxygenase enzymes by aminoacetylenic isoindoline i,3-diones " , "Inflammation and Allergy-Drug TARGET",Vol.recently accepted,No., Bentham science, International, 05/07/2012 Abstract:
      Inflammation & Allergy - Drug Targets, 2012, 11, 000-000 1 1871-5281/12 $58.00+.00 © 2012 Bentham Science Publishers Non-Selective Inhibition of Cyclooxygenase Enzymes by Aminoacetylenic Isoindoline 1,3-Diones Nidal A. Qinna*,1, Zuhair A. Muhi-eldeen2, Mohammad Ghattas3, Tawfiq M. Alhussainy1, Jenan Al-Qaisi1 and Khalid Z. Matalka1 1Department of Pharmacology and Biomedical Sciences, Faculty of Pharmacy and Medical Sciences, Petra University, Amman, Jordan 2Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy and Medical Sciences, Petra University, Amman, Jordan 3Faculty of Pharmacy, Alzaytoonah University, Amman, Jordan Abstract: The reported pharmacological activities of acetylenic and phthalimide groups promoted our interest to synthesize a novel series of N-[4-(t-amino-yl)-but-2-yn-1-yl] isoindoline-1,3-diones as anti-inflammatory compounds. The aim of this research is to investigate the selectivity of two compounds, ZM4 and ZM5, on inhibiting cyclooxygenase (COX) in vitro and in silico as well as reducing carrageenan-induced edema in rats. Oral administration of 5-20 mg/kg ZM4 and ZM5 reduced significantly carrageenan-induced edema in dose-and time dependent manner. Furthermore, the IC50 values induced by ZM4 and ZM5 were in the range of 3.0-3.6 􀀁M for COX1 and COX 2 but were higher than those induced by Diclofenac and Celecoxib, respectively. Docking of ZM4 and ZM5 in both COX enzymes, on the other hand, exhibited the conventional binding modes that are usually adopted by different non-steroidal anti-inflammatory drugs (NSAIDs). Furthermore, ZM4 and ZM5 bind to COX enzymes as strongly as Flurbiprofen and Celecoxib. In conclusion, aminoacetylenic isoindoline 1, 3-dione compounds have shown anti-inflammatory activity by inhibiting COX-1 and COX-2 enzymes. Interestingly, the best hits showed inhibition at low micromolar levels although they are not selective at this stage. Further research will be conducted to improve both selectivity and potency. Download




      K.Z.Matalka,F.Alfarh, " Antiinflammatory aminoacetylenic isoindoline-1,3-dione derivatives modulate cytokines production from different spleen cell population " , "Immunopharmacology",Vol.accepted date 24/7/2012,No.in press, elsevier, International, 07/24/2012




      Najah AL Muhtasib,El, " The role of Human xanthine oxidoreductase (HXOR), anti-HXOR antivodies and microorganisms in synovial fluid of patients with joint inflammation " , "journal",Vol.32,No.32, springer, international, 10/01/2012 Abstract:
      The Role of Human xanthine oxidoreductase (HXOR), anti-HXOR antivodies and microorganisms in synovial fluid of patients with joint inflammation




      Raghad Shakir, Zuhai, " Analgesic and toxicity studies of aminoacetylenic isoindoline-1,3-dione derivatives " , "ISRN Pharmacology",Vol.2012,No.65472, Hidawi Publishing Corporation, International, 11/28/2012 Abstract:
      we have developed a series of aminoacetylenic isoindoline-1,3-dione compounds and showed their anti-inflammatory activities by reducing carrageenan-induced rat paw edema and modulate proinflammatory and anti-inflammatory.




      Zuhair muhi-eldeen,E, " Synthesis and biological evaluation of N1,N2-bis-(4-(t-amino)-2-butynyl)phthalamides as oxotrmorine and acetylcholine antagonists " , "Medicinal Chemistry Research",Vol.22,No.4, Springer, International, 04/04/2013 Abstract:
      A seies of N1-N2-bis-(bis-t-amino)-2-butynyl)phthalamides have been synthesized and investigated for the blocking of the motor effect of oxotremorine in intact mice and for their antagonistic activity towards acetylcholine on isolated guines pig ileum preparations. all N1-N2-bis-(4-(t-amino0-2-butynyl)phthalamides showed more selectivity as oxotremorine antagonists than atropine and less potent than atropine on perpheral cholinergic antagonistic activity.




      Najah Al- Muhtaseb 1, " Dyslipidemia and Xanthine Oxidoreductase level in Jordanian Patients with Rheumatoid Arthritis " , "European Journal of Scientific research ",Vol.99,No.1, EJSR, UK, 04/08/2013 Abstract:
      Context: Rheumatoid arthritis (RA) is associated with an excess mortality from cardiovascular disease which might be due to an increased prevalence of cardiovascular risk factors such as dyslipidemia, and free radical generating enzyme such as xanthine oxidoreductase (XOR). Thus, they appear to be suitable markers for clinical studies of lipid profile and XOR level in patient with RA and related cardiovascular risk. Objectives: of the study were to assess the prevalence of blood dislipidemia and the levels of blood and synovial XOR in Jordanian patients with untreated active rheumatoid joint diseases and to investigate the clinical and biological associated factors. Methods: Synovial fluids and blood were collected from one hundred twenty seven patients with active RA (63 male and 64 female). One hundred eleven age matched individuals were included as control. Blood lipid profile, apolipoproteins (Apo), blood and synovial XOR proteins level were determined. Results: the levels of patient serum cholesterol (C), low density lipoprotein (LDL)-Cholesterol, Apo B, triglyceride (TG), very low density lipoprotein (VLDL-TG), LDL-TG, Apo C-III, Apo C-III/TG, Apo B/Apo A-I, and LDL-C/high density lipoprotein (HDL)HDL2-C ratios were significantly increased in RA patients. A significant reduction in the levels of HDL-, HDL2-, HDL3-C, serum Apo A-I, ApoA-II, HDL-Apo A-I, and HDL2-C/HDL3-C ratio were found in RA patients compared to healthy controls. Increased XOR in serum and synovial fluid were observed in the RA patients studied. . Conclusions: Abnormalities in lipids, lipoproteins, apolipoproteins and XOR were found in RA patients. Our data favor an enhanced affinity towards atherosclerosis in these patients. Management of dyslipidemia should consider as a part of cardiovascular risk management in RA patients. Attention must be paid to lipids profile for those RA patients with previous history of a cardiovascular event. Download


  • Conference paper





      Abstract:
      Synthesis of organophosphrus compounds as insecticidal agents.




      Abstract:
      Synthesis and Biological Evaluation of aminoacetylenic phthalimides . Download




      Elham Al-Quasi, " Trizoline Derivatives of Amino-Acetylenic Componuds " , "",Vol.,No., , , 12/07/2010 Abstract:
      Trizoline Derivatives of Amino-Acetylenic Componuds
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