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Name : Hadeel Tahseen Al-Sinjilawi

Academic Rank: Lecturer

Administrative Position : Faculty Academic Member

Office 7203       Ext No 7203

Email : halsinjilawi@uop.edu.jo

Specialization: الكيمياء

Graduate Of: University of Jordan

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Qualification

    Qualification

    University

    Country

    Year

    B.Sc.
    University of Jordan
    Jordan
    2008
    Master's
    University of Jordan
    Jordan
    2011



  • Journal Paper





      Hadeel T. Al-Sinjila, " Synthesis and Antibacterial Activity of Some Novel 4-Oxopyrido[2,3-a]phenothiazines " , "Arch. Pharm. Chem. Life Sci",Vol.347,No., , , 11/25/2014 Abstract:
      A series of substituted 4-oxopyrido[2,3-a]phenothiazine-3-carboxylic acids (6a–d) were prepared via cyclization of the corresponding ethyl 7-(arylthioxy)-8-nitro(or azido)-4-oxoquinoline-3-carboxylates (3a–d/4a–d), followed by hydrolysis of the resultant esters (5a–d). Among these tetracyclics, compound 6a with unsubstituted terminal benzo-ring D was the most active against representative Gram-positive and Gram-negative bacterial strains. These compounds were also active against methicillin-resistant Staphylococcus aureus (MRSA), with very low toxicity to normal cells. Virtual screening using ligand–protein dockingmodeling predicted that the compounds 6a–d are potential inhibitors of the topoisomerase IV enzyme and that hydrophobic interactions and hydrogen bonds are the majormolecular interactions between these compounds and the residues of the active site of topoisomerase IV. Download
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