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الإسم : د. كنزا منصور

الرتبة العلمية: أستاذ مساعد

المسمى الوظيفي: عضو هيئة تدريسية

المكتب 119       الرقم الفرعي 8119

بريد الكتروني: kmansoor@uop.edu.jo

التخصص: الصيدلة

جامعة التخرج: جامعة مانشستر

المؤهل العلمي

    المؤهل العلمي

    الجامعة

    البلد

    سنة الحصول على المؤهل

    البكالوريوس
    جامعة البترا
    الاردن
    2001
    الدكتوراه
    جامعة مانشستر
    المملكه المتحدة
    2006



  • Journal Paper





      Pharmaceutical Biolo, " Proanthocyanidins from Ginkgo biloba leaf extract and their radical scavenging activity, Pharmaceutical Biology, 2011 49(5):471-6 " , "",Vol.,No., , , 01/01/2011 :الملخص
      Ginkgo biloba L (Ginkgoaceae) is a traditional herbal medicinal plant for the treatment of mild to moderate cognitive disorders, tinnitus, and dementia. These uses may be correlated with the presence of radical scavenging compounds. The chemical composition and the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity of the flavan-3-ols and proanthocyanidins from G. biloba were studied. The compounds have been isolated using column chromatography on Sephadex LH-20 and MCI gel and the structures were determined on the basis of 1D- and 2D-NMR (HSQC, HMBC) experiments of their peracetylated derivatives, MALDI-TOF-MS and by acid-catalyzed degradation with phloroglucinol. The DPPH radical scavenging activities of the compounds were investigated. The new trimeric prodelphinidin, epigallocatechin-(4β→8)-epigallocatechin-(4β→8)-catechin (compound 7), has been isolated from the air-dried leaves of the title plant, in addition to catechin, epigallocatechin, gallocatechin, and three dimeric proanthocyanidins. The dimeric prodelphinidin epigallocatechin-(4β→8)-epigallocatechin (compound 6) showed the strongest DPPH radical scavenging activity, with IC(50) 1.7 μg/mL, 10 times more active than the positive control, BHT (IC(50) 17.3 µg/mL), followed by the new trimeric proanthocyanidin epigallocatechin-(4β→8)-epigallocatechin-(4β→8)-catechin with IC(50) 2.1 µg/mL. The crude extract exhibited high DPPH radical scavenging activity with IC(50) 15.5 µg/mL comparable with that of BHT. The results showed that all the isolated compounds from the tannin fraction exhibited potent free radical scavenging activities, which were higher than that of BHT, suggesting that the condensed tannins from G. biloba leaves strongly contribute to the overall antioxidant effects.




      Scientica Pharmaceut, " Polyphenols from Ginkgo biloba leaf extract, Scientica Pharmaceutica, 2010 28;78(4):897-907 " , "",Vol.,No., , , 01/01/2010 :الملخص
      By Sephadex LH-20 gel chromatography of an extract from Gingko biloba leaves, polymeric proanthocyanidins were eluted after the fractions of flavonol glycosides and biflavone glycosides. A purified proanthocyanidin polymer accounted for 86.6% of the total proanthocyanidins, and for 37.7% of the total antioxidant activity of this leaf extract. For structure elucidation, the polymer was submitted to acidic depolymerization in the presence of phloroglucinol. The structures of the resulting flavan-3-ols and phloroglucinol adducts were determined on the basis of 1D-and reverse 2D-NMR (HSQC, HMBC) spectra of their peracetylated derivatives, MALDI-TOF-MS and CD-spectroscopy. The observations resulting from the degradation with phloroglucinol were confirmed by 13C-NMR spectroscopy of the polymer. The mean molecular weight of the polymeric fraction was estimated to be 9–10 flavan-3-ol-units.




      Natural Product Rese, " Antioxidant oligomeric proanthocyanidins from Cistus salvifolius, Natural Product Research, 2006 20 (13):1216-24 " , "",Vol.,No., , , 01/01/2006 :الملخص
      The purified proanthocyanidin oligomers of Cistus salvifolius herb extract accounted for 78% of the total proanthocyanidins and 73% of the total antioxidant activity of this extract. To elucidate the structure of the oligomer, it was depolymerized by acid catalysis in the presence of phloroglucinol. The structures of the resulting flavan-3-ols and phloroglucinol adducts were determined on the basis of 1D- and reverse 2D-NMR (HSQC, HMBC) experiments of their peracetylated derivatives, MALDI-TOF-MS and CD spectroscopy. These observations resulting from the degradation with phloroglucinol were confirmed by 13C NMR spectroscopy of the oligomer. The mean molecular weight of the higher oligomeric fraction was estimated to be 5–6 flavan-3-ol-units.






  • Chapter in a Book





      2007, volume 1, page, " Gas Chromatography: Terpinoids ,Encyclopaedia of Separation Science, Elsevier, Academic Press, 2007, volume 1, pages 1-10 " , "",Vol.,No., , , 01/01/2007


  • Conference paper





      36th International S, " Stability of Australian tea tree oil (Melaleuca alternifolia) individually and in combination with topical O/W emulsions, 36th International Symposium of Essential Oils, Budapest,2005 " , "",Vol.,No., , , 01/01/2005




      54th Annual Congress, " Antioxidant oligomeric proanthocyanidins from Cistus salvifolius, 54th Annual Congress on Medicinal Plant Research, Helsinki, 2006 " , "",Vol.,No., , , 01/01/2006




      The Jordanian Intern, " Stability of curcuminoids in Javanese turmeric (C. xanthorrhiza) extract formulated into O/W emulsions ,The Jordanian International Pharmaceutical Conference, Al-Zaytoonah Private University of Jordan, 2006 " , "",Vol.,No., , , 01/01/2006




      The First Regional S, " Stability of salicin and proanthocyanidins in willow bark (Salix alba) extract formulated into O/W emulsions, The First Regional Scientific Conference on Traditional Arabic and Islamic Medicine, Amman, Jordan, 2007 " , "",Vol.,No., , , 01/01/2007




      Arab Pharmacists Con, " Microbiological Determination of Pure and Formulated Tea Tree Oil and α-Terpineol, Arab Pharmacists Conference, Amman, Jordan, 2008 " , "",Vol.,No., , , 01/01/2008




      "Pharmacy is a pivot, " Contraindications of natural drugs during pregnancy, 2nd Scientific day of Pharmaceutical Association Contraindications of natural drugs during pregnancy, 2nd Scientific day of Pharmaceutical Association "Pharmacy is a pivotal profession in community health", Zarqa, Jordan 2011 " , "",Vol.,No., , , 01/01/2011
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