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Name : Ahmad Al- Sheikh

Academic Rank: Associate Professor

Administrative Position : Faculty Academic Member

Office 8117 Ext No 8117

Email : aalsheikh@uop.edu.jo

Specialization: Chemistry

Graduate Of: Tuebingen

Qualification

Qualification	University	Country	Year
Bachelor	University of Jordan	Jordan	1994
Masters	University of Jordan	Jordan	1998
Ph.D	Tuebingen	Germany	2004

Journal Paper

Ahmed Al-sheikh, " Elimination of a Thiomethyl Substituent from an Anionic 5-Methylenebarbituric Acid Derivative by Oxidation and Substitution " , "",Vol.,No., , , 03/31/2009

Abstract:

A. Al-Sheikh, K. Sweidan, N. Kuhn, C. Maichle-Mossmer and M. Steimann, Z. Naturforsch. 64b(3), 307-312 (2009) Download

Ahmed Al-sheikh

Abstract:

A. Al-Sheikh, K. Sweidan. C. Maichle-Mossmer, M. Steimann, N. Kuhn, Z. Naturforsch. 64b(1), 101-105 (2009) Download

Kamal Sweidan, Ahmed, " Synthesis, Structure and Reactions of 1,3-Dimethyl-bis(thiomethyl)methylenebarbituric Acid " , "Z. Naturforsch",Vol.64b,No., University of Germany, Tuebingen, Germany, 01/31/2009 Abstract:

1,3-Dimethyl-5-bis(thiomethyl)methylenebarbituric acid (8) is obtained from 1,3-dimethylbarbituric acid and CS2/NEt3 followed by alkylation with methyl iodide. Compound 8 reacts with aqueous ammonia to give 5-amino(thiomethyl)methylene-1,3-dimethylbarbituric acid (9). With benzylamine, the thiomethyl substituent in 9 is replaced to give 5-amino(benzylamino)methylene-1,3- dimethylbarbituric acid (10) while with methanesulfonic acid the sulfonate salt 11 is formed. The crystal structures of 8 and 9 are reported. Download

Kamal Sweidan, Ahmed, " Synthesis of Phosphorus, Arsenic and Antimony Ylides Containing the 1,3-Dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione Fragments " , "Letters in Organic Chemistry",Vol.6,No., Bentham Science Publishers Ltd, Karatchy, Pakistan, 01/01/2009 Abstract:

The ylides Ph3E-C6H6N2O3 (7, E = P (a), As (b), Sb (c)) have been prepared through the reaction of Ph3E and 5- bromo-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione (5-bromo-1,3-dimethylbarbituric acid) 6 in the presence of triethylamine. Their characterisation was performed by nuclear magnetic resonance (NMR), mass spectrometry (MS) and elemental analysis. Download

Ahmad Al-Sheikha, Ka, " Synthesis and Crystal Structure of Triethylammonium 5-[(2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)(methylthio)methyl]-1,3-dimethylpyrimidine-2,4,6-trionate " , "Z. Naturforsch",Vol.63b,No., University of Tuebingen, Tuebingen, Germany, 04/30/2008 Abstract:

Triethylammonium 5-[(2,2-dimethyl-4,6-dioxo-1,3-dioxan- 5-ylidene)(methylthio)methyl]-1,3-dimethylpyrimidine- 2,4,6-trionate (6) is obtained as red-orange stable crystals by reaction of 5-[bis(methylthio)methylene]-2,2-dimethyl- 1,3-dioxane-4,6-dione (5) with 1,3-dimethylbarbituric acid (2) in the presence of triethylamine in excellent yield. The crystal structure of 6 confirms the negative charge to be localized at the barbituric-acid ring in its enolate form. Download

Norbert Kuhn, Ahmad , " The Crystal Structure of –Bis (thiomethyl)methylene Meldrum's Acid " , "Z. Naturforsch",Vol.62b,No., , , 11/01/2007 Abstract:

The crystal structure of 5-bis(thiomethyl)methylene Meldrum’s Acid (2) reveals a zwitterionic nature of the compound apparently influenced by both steric and electronic factors (triclinic space group P¯1, Z = 2, a = 5.489(1), b = 7.402(2), c = 14.329(3) A˚ ; α = 82.25(3), β = 82.08(3), γ = 78.59(3)◦; V = 561.7(2) ˚A3). Download

KuhnN., Eichele, K.,, " Hydrogen Bonds with Cyanide Ions The Structures of 1,3-Diisopropyl-4,5-dimethylimidazolium " , "",Vol.,No., , , 11/01/2006 Abstract:

Hydrogen Bonds with Cyanide Ions? The Structures of 1,3-Diisopropyl-4,5-dimethylimidazolium Cyanide and 1-Isopropyl-3,4,5-trimethylimidazolium Cyanide Download

Ahmed Al-sheikh, " Dihydroimidazol-2-ylidenes and Their Main Group " , "",Vol.,No., , , 10/01/2005 Abstract:

N. Kuhn and A. Al-Sheikh , Review of 2,3- Coor. Chem. Review, 249, 829-857 (2005). Download

Norbert Kuhn, Ahmad , " Zwitterionic Imidazolium and Phosphonium Derivatives of Methylenemeldrum's Acid [1,2] " , "Z. Naturforsch",Vol.60b,No., , , 08/01/2005 Abstract:

2,2-Dimethyl-4,6-dioxo-5-pyridinomethyl-1,3-dioxan-5-yl-pyridinium ylide (9) reacts with 2,3-dihydro- 1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene (1; R1 = iPr, R2 = Me) to give the zwitterionic imidazolium derivative 2,2-dimethyl-4,6-dioxo-5-(1,3-diisopropyl-4,5-dimethylimidazoliomethyl)- 1,3-dioxan-5-yl-imidazolium ylide (4) in good yield. Similarly, the phosphonium compound 2,2-dimethyl-4,6-dioxo-5-triphenylphosphoniomethyl-1,3-dioxan-5-yl-phosphonium ylide (5) is obtained from 9 and PPh3. The crystal structures of 4 and 5 are reported. Download

Norbert Kuhn Prof. D, " , On the Reaction of Meldrum's Acid with Sulfur Dichloride – Synthesis and Properties of anUncommon 1,3- Dithietane " , "",Vol.,No., , , 06/01/2005 Abstract:

The 1,3-dithietane {MelS}2 (8) is obtained from Meldrum's acid MelH2 (1, Mel = C6H6O4) and sulphur dichloride in good yield. 8 reacts with the nucleophiles PPh3 and 2,3-dihydro-1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene (12, Im) to give the zwitterionic compounds Mel-S-PPh3 (11) and Mel-S-Im (13). Aqueous ammonia gives the dianionic disulfide (NH4)2[Mel-S-S-Mel] (14). The crystal structures of 8, 11, and 14 are discussed. Download

Norbert Kuhn, Ahmed , " Synthesis and Structure of Meldrum’s Olefin [1] " , "Zeitschrift für Naturforschung B",Vol.59b,No., , , 11/01/2004 Abstract:

Diisopropylidene ethylenetetracarboxylate, Meldrum’s olefin (4, Mel2) has been prepared from [HNEt3][(Mel)2CSMe] (8) and Meldrum’s acid (1, MelH2) in moderate yield. The X-ray analysis of 4 reveals a centrosymmetrical structure in which the two six-membered rings are folded along their carboxylate carbon axes by 34.9◦) and linked by a conventional C-C double bond [1.3501(19) A° ]. The “unsymmetrical” structure of 8 is also discussed. Download

Norbert Kuhn, Ahmed , " On the Reaction of 2,3-Dihydro-1,3-diisopropyl-4,5-6-dimethylimidazol-2-ylidene with Bromine Derivatives of Meldrum's Acid, " , "",Vol.,No., , , 08/03/2004 Abstract:

The Imidazolium salts [ImH][MelBr] (7) and [ImBr][MelBr] (8) have been obtained from the carbene Im (5) and the Meldrum’s acid derivatives MelHBr (3) and MelBr2 (4). The crystal structure analyses of 7 and 8 reveal the presence of ion pairs linked by short OH (7: 2.163 A° ) and OBr (8: 2.872 A° ) contacts Download

Norbert Kuhn, Ahmed , " Synthesis andStructure of a Zwitterionic Imidazolium 1,3- dioxanide[1] " , "",Vol.,No., , , 11/01/2003 Abstract:

{Bis(methylthio)methylene}-2,2-dimethyl-4,6-dioxo-1,3- dioxane (7) reacts with cis-1,2-diamino-1,2-dicyanoethene to give 2,2-dimethyl-4,6-dioxo-5-{2-(4,5-dicyano)} imidazolio-1,3-dioxan-5-yl-imidazolium ylide (8) as a stable crystalline solid in good yield. The crystal structure of 8 × C3H6OS is discussed. Download

Norbert Kuhn, Ahmed , " 2-Amino-1,3-dimethylimidazolium 2,2-Dimethyl-4,6-dioxo-1,3-dioxanide. First Structural Characterisation of the Anionof Meldrum’s Acid [1] " , "",Vol.,No., , , 09/01/2003 Abstract:

2-Amino-1,3-dimethylimidazolium 2,2-dimethyl- 4,6-dioxo-1,3-dioxanide (6) has been obtained from the reaction of 2,2-dimethyl-4,6-dioxo-1,3- dioxan (1, “Meldrum’s acid”) and 2-imino-1,3-dimethylimidazoline (5) in excellent yield. The unit cell of 6 contains two crystallographically independent anions lying on crystallographic mirror planes. The structure of the anion is compared with that of compound 1. Download

Norbert Kuhn , Ahmed, " Novel Zwitterionic Sulfides, selenides and tellurides [1] " , "",Vol.,No., , , 02/01/2003 Abstract:

The zwitterionic compounds Im-E-Mel [9, E = S (a), Se (b), Te (c), Im = 2-{1, 3-diisopropyl-4, 5-dimethylimidazolium}, Mel = 5-{2, 2-dimethyl-4, 6-dioxo-1, 3-dioxan-5-ylide}] are obtained from the corresponding 2-chalcogeno-1, 3-diisopropyl-4, 5-dimethylimidazolines 8 and 5-bromo-2, 2-dimethyl-4, 6-dioxo-1, 3-dioxan (7) in the presence of triethylamine in excellent yields. The crystal structures of the thermally stable compounds reveal most effective charge separations from which the compounds 9 resemble closely to diaryl chalkogenides. 9b and 9c are the first selenocarbonyl and tellurocarbonyl ylides reported, to our knowledge. Download

Norbert Kuhn, Ahmed , " A New Route to Arsonium, Stibonium and Bismuthonium 2,2- Dimethyl-4,6-dioxo-1,3-dioxanides. The Crystal Structures of Ph3E-C6H6O4 (E = As, Sb, Bi). [1], " , "",Vol.,No., , , 01/01/2003 Abstract:

The ylides Ph3E-C6H6O4 [3; E As (a), Sb (b), Bi (c)] have been prepared through the reaction of Ph3E and 5-bromo-2,2- dimethyl-4,6-dioxo-1,3-dioxin (4) followed by addition of triethylamine in good yields. The crystal structures of 3 are reported. Download

Norbert Kuhn, Ahmed , " Synthesis and Structure of 1-{2,2-Dimethyl-4,6-dioxo-5-(1-pyridinio)-1,3- " , "Z. Naturforsch",Vol.58b,No., , Tuebingen, Germany, 01/01/2003 Abstract:

2-Bromo-5,5-dimethyl-4,6-dioxo-1,3-dioxine (3) reacts with pyridine and aqueous potassium carbonate to give 1-{2,2-dimethyl-4,6-dioxo-5-(1-pyridinio)-1,3-dioxan-5-yl}pyridinium ylide (5). Download

Norbert Kuhn, Ahmed , " Synthesis and Structure of 1,3-Diisopropyl-4,5-dimethylimidazolium N,N’-Diphenylureate [1] " , "Zeitschrift f¨ur Naturforschung",Vol.57b,No., , , 11/01/2002 Abstract:

1,3-Diisopropyl-4,5-dimethylimidazolium diphenylureate (4) has been obtained from 2,3- dihydro-1,3-diisopropyl-3,4-dimethylimidazol-2-ylidene (3) and N,N'-diphenylurea in good yield. The crystal structure of 4 contains dimeric ureate anions linked by unsymmetrical NHN hydrogen bonds while only weak interactions are detected between the imidazolium cations and the anions. Download

Ahmed Al-sheikh, " Determination of Nchloramines in As-Samra chlorinated wastewater and their effect on the disinfection process " , "",Vol.,No., , , 11/01/2001 Abstract:

. M. Fayyad and A. Al-Sheikh, , Water Research, 35(5), 1304-1310. (2001). Download

Kamal Sweidan, Qutai, " Novel Derivatives of 1,3-Dimethyl-5-methylenebarbituric Acid " , "Letters in Organic Chemistry",Vol.1,No.6, Bentham Science Publishers Ltd., Karatchy, Pakistan, 12/01/2009 Abstract:

The ability of the pyridinium adduct of 1,3-dimethyl-5-methylenebarbituric acid (2) to undergo nucleophilic substitution reaction has been examined. Various types of nucleophiles, including cyanide, barbiturate, sulfide anions and 1,2-bis(diphenylphosphino)ethane substitute the pyridinium fragment in 2 leading to synthesis of new organic derivatives. Keywords: 1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione (1,3-dimethylbarbituric acid), zwitterionic pyridinium adduct, Download

K. Sweidan,1 A. Al-S, " NOVEL SYNTHETIC ROUTES TO 1,3,1,3-TETRAMETHYL- HYDURILIC ACID AND TETRAMETHYLALLOXANTINE (AMALIC ACID) AND THEIR CRYSTAL STRUCTURES " , "Journal of Structural Chemistry",Vol.51,No.4, Springer Science+Business Media, Inc., Mosco, Russia, 01/01/2010 Abstract:

1,3,1,3-Tetramethylhydurilic acid (1) and tetramethylalloxantine (5) were prepared by simple novel methods. The crystal structures of the compounds 1 and 52(DMSO) are reported. Download

Norbert Kuhn, Ahmed , " The Structural Chemistry of 2-Methylenimidazolines [1] " , "Z. Naturforsch. ",Vol.60b,No., , , 11/01/2005 Abstract:

The 2-methylenimidazolines ImC(CN)2 (6a – c, Im = 1,3-dialkyl-4,5-dimethylimidazol-2-ylidene) are prepared by the reaction of the imidazolium salts [ImBr]Br (5) and malodinitrile while ImC{C(O)Ph}2 (7) is obtained from ImCH2 (2) and benzoic fluoride. Both the structural data of 6b, 6c, and 7 and the 13C NMR data demonstrate the influence of steric and electronic effects on the charge separation and the nonplanar arrangement of the substituents attached at the carbon atoms of the central olefinic bond. Download

Ahmed Al-Sheikh, Kamal Sweidan, Munjed Ibrahim, Mohammed Alarjah and Norbert Kuhn, " Synthesis of novel derivatives of pyrano[2,3-d]pyrimidine via Intramolecular cyclocondensation reaction under acidic and basic conditions " , "Letters in Organic Chemistry",Vol.9,No.6, , , 12/01/2012

Wael Abu Dayyih, Eyad Mallah, Kamal Sweidan, Ahmed Al-Sheikh and Manfred Steimann, " Crystal structure of 1,3-diisopropyl-4,5-dimethylimidazolium oxalic acid monomethyl ester, C14H24N2O4, " , "Z. Kristallogr. NCS,",Vol.,No., , , 08/01/2013

Eyad Mallah, Ahmed Al-Sheikh, Kamal Sweidan, Wael Abu Dayyih and Manfred Steimann,, " Crystal structure of 5- [bis(methylsulfonyl)methyl]-1,3-dimethyl-5- (methylsulfonyl) pyrimidine-2,4,6(1H,3H,5H)-trione, " , " Acta Cryst",Vol. E71,No., , , 01/01/2015

Riad Awad, Eyad Mallah, Kamal Sweidan, Ahmed AlSheikh, Wael Abu Dayyih, and Manfred Steimann,, , " Synthesis and crystal structure of 1,3-diisopropyl-4,5- dimethylimidazolium 4-methyl-benzenesulfinate " , "J. Chem. Pharm. Res.136",Vol.6,No.12, , , 11/01/2014

Ahmed Al-Sheikh ,Masuma Begum , Bian Zhang , Richard A. Lewis , Nicholas E. E. Allenby , Paul G. Waddell and Bernard T. Golding , " Molecular Diversity via Tetrasubstituted Alkenes Containing a Barbiturate Motif: Synthesis and Biological Activity " , "molecules",Vol.25,No., MDPI, switzerland, 12/11/2020

1. Ahmed Al-Sheikh, Eyad Mallah, Kamal Sweidan, Qais Abualassal, Zead Abudayeh, Luay Abu-Qatouseh, Manfred Steimann, , " Synthesis, hydrogen bond interactions and crystal structure elucidation of some stable 2H-imidazolium salts " , "Z. Naturforsch. ",Vol.77,No., De Gruyter, Konstanz, Germany, 11/26/2021 Abstract:

Reaction of 1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene (1) with phthalimide, quinazolinedione, thiophenole and 4-pyridinethiole led to the formation of the hydrogen-bonded salts, imidazolium phthalimide (2), imidazolium quinazolinedione (3), imidazolium thiophenolate (4) and imidazolium 4-pyridinethiolate (5), respectively, in good yield. In crystals of 2, the anion is linked to the imidazolium cation by a C–H···O hydrogen bond, while in 3 and 5 C–H···N hydrogen bonds are observed. In 4, the imidazolium ion is linked to the anion by C–H···S hydrogen bonds. In compounds 2, 3 and 5, the interionic hydrogen bonds are close to linearity, while the interionic hydrogen bond angle in 4 is 148.5(9)°.

Patent

Al-Sheikh, Ahmad; Arafat, Tawfiq; Abuqatouseh, Luay; Mallah, Eyad, " SUBSTITUTED QUINOLONE COMPOUNDS, THEIR USE IN THE TREATMENT OF CANCER, AND A METHOD FOR PREPARATION " , "PCT Int. Appl. (2020), WO 2020136693 A1 20200702",Vol.WO 2020/136693 Al,No., WIPO, Amman, Jordan, 07/02/2020

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